Immunohistochemistry of Bone-Marrow Biopsy

Stefano A. Pileri Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, BolognaCorrespondence[email protected]

Giovanna Roncador Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Claudio Ceccarelli Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Milena Piccioli Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Elena Sabattini Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Aspasia Briskomatis Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Donatella Santini Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Ornella Leone Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Pier Paolo Piccaluga Second Service of Pathologic Analomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Via Massarenti, 9–40138, Bologna

Lorenzo Leoncini Institute of Pathology, Siena University, he Scotte Hospital, Via delle Scotte, 53100, Siena

Brunangelo Falini Haematopathology Laboratory, Institute of Haematologv, Perugia University, Monteluce Hospital, Piazzetta Monteluce, 06100, Perugia, Italy

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Abstract

In a percentage of cases, conventional morphologic evaluation of bone-marrow needle biopsy (BMNB) in insufficient to achieve a firm diagnosis. Under these circumstances, irnmunohistochemistry plays a basic role, providing an easy and objective key for the interpretation of the pattern observed in most instances. Herein, the authors focus on the technical procedures, which allow extensive application of immunohistochemistry to the study of BMNB, as well as on the panels of antibodies needed for the identification of the most relevant conditions.

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Immunohistochemistry of Bone-Marrow Biopsy

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Immunohistochemistry of Bone-Marrow Biopsy

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