Successful Treatment of Aplastic Anemia with G-CSF and High Dose Erythropoietin

Kazuhiro Niship Leukaemia Research Fund Centre at the Institute of Cancer Research, London, UK; The Second Department of Internal Medicine, Mie University School of Medicine, Tsu, 514, Japan

Yoshinori Suzuki Leukaemia Research Fund Centre at the Institute of Cancer Research, London, UK

Nobuyuki Minami The Second Department of Internal Medicine, Mie University School of Medicine, Tsu, 514, Japan

Ian Titley Leukaemia Research Fund Centre at the Institute of Cancer Research, London, UK

Kenkich Kita The Second Department of Internal Medicine, Mie University School of Medicine, Tsu, 514, Japan

Hiroshi Shiku The Second Department of Internal Medicine, Mie University School of Medicine, Tsu, 514, Japan

Abstract

We report the successful treatment of pancytopenia with G-CSF and high dose erythropoietin (Epo) in an elderly patient diagnosed with aplastic anemia (AA). Furthermore this effect is dose dependent for Epo in vivo. Detection of apoptosis by gel electrophoresis shows that high dose Epo protects bone marrow mononuclear cells from spontaneous apoptosis in vitro. These findings may explain some of the mechanisms of aplastic anemia.

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Successful Treatment of Aplastic Anemia with G-CSF and High Dose Erythropoietin

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Successful Treatment of Aplastic Anemia with G-CSF and High Dose Erythropoietin

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