Hepatic Outflow Obstruction and Liver Failure Due to Leukemic Cell Infiltration in Chronic Lymphocytic Leukemia

Frederico Costa Division of Hematological/Oncology

C. Galen Choy Division of Hematological/Oncology

Karen Seiter Department of Medicine, The New York Medical College, Valhalla, NY

Lucy Hann Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY

Swan N. Thung The Lillian and Henry M. Stratton-Hanspopper Department of Pathology, The Mt. Sinai School of Medicine, New York, NY, USA

Joseph Michaeli Division of Hematological/Oncology

Abstract

We report a patient with advanced progressive CLL who presented with liver failure and hepatic venus outflow obstruction (HVOD) due to lymphocytic leukemic infiltrates. Initiation of antileukemic therapy resulted in a rapid and prompt resolution of these life-threatening complications. This is apparently the first report of a CLL patient with HVOD and liver failure, attributable to liver infiltration by leukemic cells.

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Hepatic Outflow Obstruction and Liver Failure Due to Leukemic Cell Infiltration in Chronic Lymphocytic Leukemia

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Hepatic Outflow Obstruction and Liver Failure Due to Leukemic Cell Infiltration in Chronic Lymphocytic Leukemia

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