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Abstract
Fifty-seven consecutive patients with Waldenstrom's Macroglobuliemia were studied retrospectively for autoimmune manifestations. 28 patients or 51 % (16 women and 13 men) had clinical and/or serological autoimmune manifestations, two or more of these being concomitant in 20 (12 women and 8 men). The predominant findings were Coombs’ positive autoimmune hemolytic anemia (16 %). seropositive rheumatoid arthritis (16 %), inflammatory gastric ulcer with parietal cell autoantibodies (12 %), and IgM-cardiolipin syndrome (11 %). 40 % of the autoimmune manifestations were present at the time of diagnosis of the Waldenstrom's Macroglobulinaemia and 60 % were observed over a mean period of 4.7 years. All patients had an IgM M-component. There was no correlation between autoimmunity and the size of the M-component or the degree of hypo-IgG and hypo-IgA gammaglobulinemia. The only correlation between autoimmunity and infection was found in patients with gastric ulcer and parietal cell autoantibodies, in whom the infection was caused by Helicobacter pylori.