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Leukemia & Lymphoma Volume 34, 1999 - Issue 3-4
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Original Article

Acute Neutrophilic Dermatosis Induced by All-Trans-Retinoic Acid Treatment for Acute Promyelocytic Leukemia

Itai Levi Institute of Hematology, The Chaim Sheba Medical Center. Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel
,
Pia Raanani Institute of Hematology, The Chaim Sheba Medical Center. Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, IsraelCorrespondence[email protected]
,
Bruria Shalmon Institute of Hematology, The Chaim Sheba Medical Center. Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel
,
Regina Schiby-Brilliant Department of Pathology, The Chaim Sheba Medical Center. Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel
&
Isaac Ben-Bassat Institute of Hematology, The Chaim Sheba Medical Center. Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel
Pages 401-404 | Accepted 30 Sep 1998, Published online: 01 Jul 2009
 
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Abstract

All-trans-retinoic acid (ATRA) is considered the recommended induction treatment for acute promyelocytic leukemia (APL). Although the dermatological side effects associated with ATRA treatment are relatively common, acute neutrophilic dermatosis (Sweet's syndrome) has only been rarely reported. We describe such a case who responded to chemotherapy and not to low doses of corticosteroids.

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