Granulocyte-Colony Stimulating Factor (G-CSF)-Primed, Delayed Marrow Harvests as a Source of Hematopoietic Stem and Progenitor Cells for Allogeneic Transplantation

G. L. Phillips Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical CenterCorrespondence[email protected]

D. D. Davey Deparmtent of Pathology and Laboratory Medicine, University of Kentucky, Chandler Medical Center, 800 Rose Street cc-301, Lexington, KY, A0536-0093, USA

G. A. Hale Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical Center

K. W. Marshall Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical Center

R. K. Munn Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical Center

R. Nath Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical Center

D. E. Reece Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical Center

G. Van Zant Blood and Marrow Transplant Program, Division of Hematology/Oncology, Department of Medicine and Markey Cancer Center, University of Kentucky, Chandler Medical Center; Deparmtent of Pathology and Laboratory Medicine, University of Kentucky, Chandler Medical Center, 800 Rose Street cc-301, Lexington, KY, A0536-0093, USA

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Abstract

We evaluated the ability of G-CSF to increase the number of hematopoietic stem cells obtained by “delayed” BM harvest for allogeneic transplantation. Five normal donors received G-CSF lOmcg/kg/day 5 followed by repeat PB and BM assays at day 6 and 16, and BM harvest at day 16. Stem cells were not increased in the BM at day 16. Five patients underwent BMT and engrafted at +10 to +19 days. While the tested strategy offers no intrinsic advantages, its potential cannot be evaluated fully without alternative timing and/or additional, “early acting” growth factors.

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Granulocyte-Colony Stimulating Factor (G-CSF)-Primed, Delayed Marrow Harvests as a Source of Hematopoietic Stem and Progenitor Cells for Allogeneic Transplantation

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Granulocyte-Colony Stimulating Factor (G-CSF)-Primed, Delayed Marrow Harvests as a Source of Hematopoietic Stem and Progenitor Cells for Allogeneic Transplantation

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