Comparative Genomic Hybridization and Conventional Cytogenetic Analyses in Childhood Acute Myeloid Leukemia

Tarja Huhta Depariment of Medical Genetics, Haartman Institute University of Helsinki, P.O. Box 21, FIN-00014, Helsinki

Kim Vetenranta Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children nd Adolescents, Helsinki University Central Hospital, P.O., Box 281, FIN-00029 HUCH, Helsinki

Kristina Heinonen Chromosome and DNA Laboratory

Jukka Kanerva Department of Clinical Chemistry, Kuopio University Hospital, FIN-70210, Kuopio

Marcelo L. Larramendy Depariment of Medical Genetics, Haartman Institute University of Helsinki, P.O. Box 21, FIN-00014, Helsinki

Eija Mahlamäki Department of Clinical Chemistry, Kuopio University Hospital, FIN-70210, Kuopio

Ulla M. Saarinen-Pihkala Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children nd Adolescents, Helsinki University Central Hospital, P.O., Box 281, FIN-00029 HUCH, Helsinki

Sakari Knuutila Depariment of Medical Genetics, Haartman Institute University of Helsinki, P.O. Box 21, FIN-00014, Helsinki; Laboratory of Medical Genetics, Helsinki University Central Hospital, P.O. Box 404, FIN-00029 HUCH, Helsinki, FinlandCorrespondence[email protected]

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Abstract

Comparative genornic hybridization (CGH) analysis was performed on bone marrow specimens from 19 children with acute myeloid leukemia (AML) at diagnosis. The results of CGH were compared to those of conventional cytogenetic analysis. The most common CGH aberrations were gains of whole chromosomes 6 and 8, both of which appeared three times. Two losses were seen twice; losses of whole chromosomes 7 and X. The CGH findings were concordant with the results of conventional karyotyping. CGH did not add new information to the karyotypes. Since no high-level amplification was found among the samples and standard karyotyping was highly successful, we do not advocate routine use of CGH in the diagnostic evaluation of childhood AML.

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Comparative Genomic Hybridization and Conventional Cytogenetic Analyses in Childhood Acute Myeloid Leukemia

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Comparative Genomic Hybridization and Conventional Cytogenetic Analyses in Childhood Acute Myeloid Leukemia

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