Epic as an Effective, Low Toxicity Salvage Therapy for Patients with Poor Risk Lymphoma Prior to Beam High Dose Chemotherapy and Peripheral Blood Progenitor Cell Transplantation

Abstract

We treated 33 patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD) with a combination of etoposide, prednisolone, ifosfamide and car-boplatin (EPIC). After a median of two courses (range 1–5) complete response was achieved in 7 (22%) patients and partial response in 12 (37%) patients, an overall response rate of 59%. The regimen was well tolerated with myelosuppression being the most common toxicity. There were no toxic deaths. 25 (78%) patients were able to proceed to high dose therapy (BEAM) with peripheral blood progenitor cell transplantation either immediately post EPIC or following further salvage therapy. Most patients mobilised peripheral blood progenitor cells well and 24 out of 25 patients subsequently undergoing autologous transplantation had rapid regeneration of counts. EPIC is an effective salvage therapy in the majority of patients with relapsed or refractory lymphoma and does not appear to be toxic to stem cells. Although severe, myelosuppression is of short duration and the generally low toxicity enables patients lo procccd lo successful peripheral blood stem cell harvest and transplantation.

Key Words:

• EPIC lymphoma relapse salvage chemotherapy