Microsatellite Instability as a Potential Marker for Poor Prognosis in Adult T Cell Leukemia/Lymphoma

Yoshihito Hayami Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Hirokazu Komatsu Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Shinsuke Iida Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, NagoyaCorrespondence[email protected]

Atae Utsunomiya Second Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima, Japan

Shuichi Hanada Second Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima, Japan

Xu Jian Hua Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Ni Huiping Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Shinsuke Harada Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Kazuya Tsuboi Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Shogo Banno Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Atsushi Wakita Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Taiji Kato Department of Bioregulation Research, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

Ryuzo Ueda Second Department of Internal Medicine, Nagoya City University School of Medicine, Mizuho-ku, Nagoya

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Abstract

Microsatellite instability (MSI) represents a replication error resulting from the dysfunction of mismatch repair gene products. In this study, MSI was analyzed in 18 patients with various subtypes of adult T cell leukemia/lymphoma (ATL/L). Using six different microsatellite loci, we defined MSI as positive when replication errors were observed in at least two loci. The MSI was positive in four cases (22.2%) with acute type ATL, who tended to show more prognostically unfavorable factors and shorter overall survival. These results suggest that genomic instability may be associated with tumor progression rather than the development of ATL/L itself. In addition, the presence of the MSI at initial presentation could appear to warrant consideration as an additional prognostically unfavorable factor.

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Microsatellite Instability as a Potential Marker for Poor Prognosis in Adult T Cell Leukemia/Lymphoma

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Microsatellite Instability as a Potential Marker for Poor Prognosis in Adult T Cell Leukemia/Lymphoma

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