Monosomy X as the Sole Cytogenetic Abnormality in Acute Lymphoblastic Leukemia: A Report of Two New Patients

Abstract

Monosomy X as the sole acquired cytogenetic abnormality is usually found in myeloid hematological malignancies, especially those with myelodysplastic features. Only three cases of acute lymphoblastic leukemia (ALL) with this abnormality have been previously reported. We add two cases to this series and comment on the likelihood of a tumor suppressor gene being located on the X chromosome.

Key Words:

• acute leukemia
• monosomy X
• cytogenetics
• tumor suppressor gene
• AFX gene
• GM-CSF receptor