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Abstract
MicroRNAs (miRNAs) have emerged as novel post-transcriptional regulators of gene expression. These short non-coding RNAs are involved in diverse biological processes and their dysregulation is often observed under diseased conditions. Therefore, miRNAs hold great potential as clinical biomarkers of physiological and pathological states and extensive efforts are underway to develop efficient approaches for their detection. We review recent advances and discuss the promises and pitfalls of emerging methods of miRNA profiling and detection.
Acknowledgments
This research was funded by NIH/NCI (CA137513), DOD/US Army (PC0739930, PC093309) and USAMCI.
Conflict of interest statement: The authors have no potential conflict of interest to disclose.