Advanced search
Publication Cover
Journal of Drug Targeting Volume 24, 2016 - Issue 2
Submit an article Journal homepage
419
Views
15
CrossRef citations to date
0
Altmetric
Original Article

Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

Mingliang FanState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
,
Xiaofei LiangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
,
Danbo YangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
,
Xiaorong PanState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
,
Zonghai LiState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
,
Hongyang WangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
&
Bizhi ShiState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaCorrespondence[email protected]
 show all
Pages 111-119 | Received 09 Jan 2015, Accepted 02 Jun 2015, Published online: 15 Jul 2015
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.

Declaration of interest

The authors report no declarations of interest. This work was supported by the Supporting Program of the “Twelfth Five-year Plan” for Science and Technology Research of China (Grant No. 2012ZX10002014-006), National Natural Science Foundation of China (No. 81302708), Medical-Engineering Joint Funds of Shanghai Jiao Tong University (No. YG2013MS41) and Innovation Fund from Shanghai Cancer Institute (No. SB14-05).

Supplementary material available online

Supplementary Figures S1-S2

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery
Source: Figshare
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
Source: Proceedings of the National Academy of Sciences
Optimizing tumor targeting of the lipophilic EGFR-binding radiotracer SKI 243 using a liposomal nanoparticle delivery system
Source: Elsevier BV
Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo
Source: Elsevier BV
A review of stimuli-responsive nanocarriers for drug and gene delivery
Source: Elsevier BV
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
Source: Elsevier BV
Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
Source: Elsevier BV
Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations.
Source: American Chemical Society (ACS)
PEG-based micelles as carriers of contrast agents for different imaging modalities
Source: Elsevier BV
Targeting of drugs and nanoparticles to tumors
Source: Rockefeller University Press
Utilization of monoclonal antibody-targeted nanomaterials in the treatment of cancer
Source: Informa UK Limited
Growth Suppression of Human Hepatocellular Carcinoma Xenografts by a Monoclonal Antibody CH12 Directed to Epidermal Growth Factor Receptor Variant III
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
EGFR and cancer prognosis
Source: Elsevier BV
Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length
Source: American Chemical Society (ACS)
Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery
Source: Figshare
PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors
Source: Wiley
Improving Penetration in Tumors With Nanoassemblies of Phospholipids and Doxorubicin
Source: Oxford University Press (OUP)
Nanomaterials in Cancer-Therapy Drug Delivery System
Source: American Scientific Publishers
Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles
Source: Elsevier BV
Epidermal Growth Factor Receptor-targeted 131I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene
Source: Elsevier BV
A Novel Peptide Specifically Binding to Nasopharyngeal Carcinoma For Targeted Drug Delivery
Source: American Association for Cancer Research (AACR)
Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer
Source: American Society of Clinical Oncology (ASCO)
Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation
Source: Mary Ann Liebert Inc
Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics
Source: Wiley
Epidermal Growth Factor Receptor Targeted Nuclear Delivery and High-Resolution Whole Cell X-ray Imaging of Fe3O4@TiO2 Nanoparticles in Cancer Cells
Source: American Chemical Society (ACS)
Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo
Source: American Chemical Society (ACS)
Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles.
Source: American Chemical Society (ACS)
Using doxorubicin and siRNA-loaded heptapeptide-conjugated nanoparticles to enhance chemosensitization in epidermal growth factor receptor high-expressed breast cancer cells
Source: Informa UK Limited
A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics
Source: Elsevier BV
Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.
Source: Proceedings of the National Academy of Sciences

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.