Erythrocyte Markers of Oxidative Stress in Higher Age-Group Preeclamptic and Normal Pregnant Mothers

Abstract

Preeclampsia can have significant impact on health of both mother and fetus. It had been proposed that maternal endothelial cell dysfunction is the key event resulting in the diverse clinical manifestations of preeclampsia and evidence has since accumulated. Research in recent times is indicative of the role of oxidative stress in the endothelial cell dysfunction. Preeclampsia is more common in first pregnancy and studies have further shown an increase in risk of preeclampsia with maternal age. The aim of this study was to explore the status of oxidative stress in higher age-group preeclamptic and normal pregnant mother. The study included 20 normal pregnant women and 60 preeclamptic women. They were allocated into 4 subgroups between ages 20–25, 26–30, 31–35, and 36–40. Erythrocytes were analyzed for the following antioxidant enzymes, i.e., glutathione peroxidase, superoxide dismutase and catalase.Lipid peroxidation product, malondialdehyde, was analyzed to determine oxidative stress. The results showed an increase in oxidative stress, and high magnitude suppression/decrease in antioxidant enzymes activities in erythrocytes with increase in age groups in both preeclamptic and normal pregnant women. This indicates that an increase in the risk of preeclampsia with maternal age could be due to an increase in oxidative stress with age. This further attests to the role of oxidative stress in preeclampsia.

Keywords:

• Oxidative stress
• Preeclampsia
• Pregnancy
• Eclampsia