Phosphodiesterase Inhibitor Effect on Small Artery Function in Preeclampsia

Abstract

Objective. To determine if the phosphodiesterase type 5 inhibitor, sildenafil citrate improves endothelial-dependent relaxation of small arteries from women with preeclampsia. Methods. Myometrial and omental biopsies were taken from women participating in a randomized placebo-controlled trial using sildenafil citrate in women with preeclampsia. Vasoconstriction and endothelial-dependent relaxation of small arteries was measured utilizing wire myography. Results. Vasoconstriction and endothelial-dependent relaxation of myometrial and omental arteries were not altered in women taking sildenafil. Conclusion. Acute effects may have been lost as sildenafil administration occurred many hours prior to myography. Plasma sildenafil levels may have been lower than required for vascular response.

• Phosphodiesterase inhibitors
• Preeclampsia
• Small arteries
• Endothelium

ACKNOWLEDGMENTS

We thank all the women who took part in this study and the staff at the participating hospitals for all their help.

Funding. This study was funded by Pfizer UK Ltd. and Tommy's: the baby charity. RAS was funded by Pfizer UK Ltd. PN Baker was Primary Investigator on University of Manchester research grants funded by Pfizer UK Ltd.