Prediction of Preeclampsia and Delivery of Small for Gestational Age Babies Based on a Combination of Clinical Risk Factors in High-Risk Women

Abstract

Objective. To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women. Methods. Individual risk scores based on clinical risk factors were calculated using logistic regression and validated in 1687 women with obesity in first pregnancy, chronic hypertension, or previous preeclampsia. Results. The risk of preeclampsia varied from 7% in obese primiparae without hypertension to 30% when previous preeclampsia and chronic hypertension occurred together. A prediction model incorporating these risk factors had a sensitivity of 48 and 89% for preeclampsia delivered <34 weeks' gestation. Conclusion. Multiple clinical risk factors increase the risk of preeclampsia and SGA.

• Preeclampsia
• SGA
• Prediction
• Risk factors

ACKNOWLEDGMENTS

This project was supported by the Foundation of Science Research and Technology (NERF grant UOAX0407) as part of the work of the Screening of Pregnancy Endpoints (SCOPE) consortium. The VIP study was funded by the Wellcome Trust (registered charity number 210183) and Tommy's the Baby Charity (registered charity number 1060508).

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.