Correlation of Cystatin-C with Glomerular Filtration Rate by Inulin Clearance in Pregnancy

Abstract

Objective. To test utility of cystatin-C as a marker of glomerular filtration rate during pregnancy, we performed serial correlations with inulin clearance during pregnancy and postpartum. Methods. Twelve subjects received inulin infusions and serum cystatin-C at three time points. Pearson's correlation coefficient was calculated. Results. Cystatin-C levels ranged 0.66–1.48 mg/L during pregnancy, and 0.72–1.26 mg/L postpartum. Inulin clearance ranged 130–188 mL/min during pregnancy, and 110–167 mL/min postpartum. Cystatin-C did not correlate with inulin clearance at any time point. Conclusion. Serum cystatin-C did not correlate with inulin clearance during pregnancy or postpartum.

• Cystatin-C
• Glomerular filtration rate
• Inulin
• Kidney function test
• Pregnancy

ACKNOWLEDGMENTS

Funding. This work was supported by National Institutes of Health GCRC's Grant M01-RR02635. In addition, EWS received support from K24 RR0186-13-01 and ARS received support from the National Institutes of Health Training Grant T32HL007609-23 and the Scholars in Clinical Sciences Program, K30RR022292-07. SAK is an investigator with the Howard Hughes Medical Institute.

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.