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Clinical and Experimental Hypertension Volume 32, 2010 - Issue 7
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Research Article

The Paradox of Dopamine and Angiotensin II-Mediated Na+, K+-ATPase Regulation in Renal Proximal Tubules

Linan Zhang Pharmacy Department, Hebei University of Science and Technology, Hebei, ChinaCorrespondence[email protected] [email protected]
,
Fang Guo Department of Pharmacology, Hebei Medical University, Hebei, China
,
Huicai Guo The School of Public Health, Hebei Medical University, Hebei, China
,
Haiyan Wang Pharmaceutical Preparation Section, Shijiazhuang Municipal No. 3 Hospital, Hebei, China
,
Zhe Zhang The Clinical Trial Center, People's Hospital of Hebei Province, Hebei, China
,
Xu Liu School of Basic Medical Sciences, Peking University, Hebei, China
,
Xiaolu Shi The Institute of Molecular Medicine, Peking University, Beijing, PR China
,
Xiangbo Gou Department of Pharmacology, North China Coal Medical University, Hebei, China
,
Qian Su Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai, China
,
Jian Yin Department of Pharmacology, Hebei Medical University, Hebei, China
&
Yongli Wang Department of Pharmacology, Hebei Medical University, Hebei, ChinaCorrespondence[email protected] [email protected]
 show all
Pages 464-468 | Received 28 Oct 2009, Accepted 03 Dec 2009, Published online: 28 Oct 2010
 
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Abstract

Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na+ and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na+, K+-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA α1-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-β, PKC-ζ), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.

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