Association Between Alcohol Intake and Metabolic Syndrome in Patients with Hypertension

Abstract

The aim of this study was to determine how alcohol consumption influences metabolic syndrome in patients with hypertension. The subjects were 3938 male workers being treated with anti-hypertensive drugs and they were divided into four groups by average ethanol intake [non-, light (<22 g/day), moderate (≥22 and <44 g/day), and heavy (≥44 g/day) drinkers]. The relationships of alcohol intake with atherosclerotic risk factors and metabolic syndrome were investigated. Waist circumference and hemoglobin A1c were significantly smaller and lower, respectively, in light, moderate, and heavy drinkers than in nondrinkers. Systolic blood pressure and log-converted triglyceride were significantly higher in heavy drinkers than in nondrinkers. HDL cholesterol was significantly higher in all of the drinker groups than in nondrinkers and tended to be higher as alcohol intake increased. Prevalence of metabolic syndrome was significantly lower in light, moderate, and heavy drinkers than in nondrinkers. Age- and smoking history-adjusted odds ratios (ORs) vs. nondrinkers for metabolic syndrome were significantly low in light drinkers (OR = 0.71, 95% confidence interval [CI]: 0.56–0.89), moderate drinkers (OR = 0.64, 95% CI: 0.54–0.75) and heavy drinkers (OR = 0.68, 95% CI: 0.57–0.82). The results suggest that alcohol drinking is associated with a lower risk of metabolic syndrome in patients with hypertension.

• alcohol drinking
• anti-hypertensive therapy
• dyslipidemia
• diabetes mellitus
• metabolic syndrome
• visceral obesity

ACKNOWLEDGMENT

This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (No. 21390211).

Declaration of interest: The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.