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Abstract
Obesity and excessive drinking are major risk factors for development of hypertension. We aimed to explore association of body mass index (BMI) and alcohol intake with isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and combined systolic/diastolic hypertension (SDH) among Shandong Shengli Oil field workers. A total of 26,681 subjects were cross-sectionally analyzed. Statistical calculations included polytomous logistic regression and interaction analysis. After assigning normotensives as a reference, the odds of being ISH decreased by 4% for moderate drinkers, whereas that of being IDH and SDH increased significantly by 1.50 and 1.15 folds (P < 0.001). The odds for heavy drinkers of being ISH, IDH, and SDH increased by 1.38, 2.41, and 2.25 folds, respectively (P < 0.001). For BMI, the odds of being ISH, IDH, and SDH increased in a dose-response manner (P < 0.001). For patients with BMI of [23, 25), [25, 27), [27, 30) and ≥ 30 kg/m2, the odds (95% confidence interval (CI)) of being SDH increased significantly by 2.28 (2.07–2.50), 3.22 (2.93–3.55), 5.44 (4.93–6.01), and 8.45 (7.31–9.77) folds, respectively. Interaction analysis indicated that BMI and alcohol intake were interactively associated with ISH (P ≤ 0.045) rather than IDH (P ≥ 0.161). Our results demonstrated that BMI and alcohol intake interactively influenced systolic hypertension, especially for overweight and obese patients.
ACKNOWLEDGMENTS
This work was supported by the Shanghai “Chen Guang” Project (09CG12), the Natural Science Foundation of Shanghai (09ZR1426200), and the National Science Foundation for Young Scientists of China (grant number 30900808).
Supplementary Material Available Online
• Four figures
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the papers.