Individual and Concomitant Effects of Cardioprotective Programs on Cardiac Apelinergic System and Oxidative State in └-NAME-Induced Hypertension

Abstract

The effect of aerobic training and Ferula gummosa supplementation (90 mg/kg) on apelinergic system and markers of cardiac stress in hypertensive rats were studied. Chronically administered l-NAME resulted in an increased level of angiotensin-converting enzyme (ACE), malondialdehyde (MDA), and high-sensitive C-reactive protein (hs-CRP), and also reduced the levels of apelin, apelin and its receptor (APJ), and nitric oxide (NO) and the total antioxidant capacity (TAC), when compared with the control group. The combination of aerobic exercise and Ferula gummosa decreased MDA and hs-CRP and significantly increased cardiac apelinergic system, NO, and TAC, when compared with the control and the l-NAME groups. A rationale for an inhibitory role and a cardioprotective effect of aerobic exercise training in the attenuation of hypertension-induced cardiotoxicity was developed.

• aerobic training
• oxidative stress
• hypertension
• apelinergic system
• cardiovascular disease