Hypertension subtypes and risk of cardiovascular diseases in a Mongolian population, inner Mongolia, China

Abstract

Background: There have been no reports about the effects of hypertension subtypes on the future cardiovascular events among Mongolian people, China. Methods and results: From June 2003 to July 2012, we conducted a prospective study to assess the association of hypertension subtypes with future risk of cardiovascular events including stroke and coronary heart disease among a Mongolian cohort of 2589 adults in China. According to the baseline blood pressure levels, the subjects were divided into those with normal blood pressure, prehypertension, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and combined systolic and diastolic hypertension (SDH). Cox proportional hazards models were used to evaluate the association between blood pressure subtypes and risk of cardiovascular diseases. After adjustment for age and gender, hazard ratios (95% confidence intervals) of cardiovascular diseases were 1.75(0.92–3.33), 2.11(0.95–4.70), 2.14(1.01–4.56) and 5.31(2.86–9.77) for pre-hypertension, ISH, IDH and SDH, respectively, compared with normal blood pressure. Furthermore, after adding other cardiovascular risk factors to adjustment, hazard ratios(95% confidence intervals) of cardiovascular diseases were 1.74(0.92–3.31), 2.00(0.88–4.54), 2.20(1.02–4.74) and 4.92(2.62–9.26) for pre-hypertension, ISH, IDH and SDH, respectively, compared with the normal blood pressure group. Conclusions: IDH and SDH were significantly associated with the increased risk of cardiovascular diseases; this study suggests that carefully monitoring and actively treating the subjects with IDH should be an important strategy for CVD prevention among Mongolian population.

• Cardiovascular diseases
• hypertension
• Mongolian

Acknowledgements

We deeply appreciate the participants in the study, and thank Kezuohou Banner Center for Disease Prevention and Control and Naiman Banner Center for Disease Prevention and Control for their support and assistance.

Declaration of interest

This study was supported by National Natural Science Foundation of China (grant Nos. 81172761 and 30972531) and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Yonghong Zhang has received grants (#81172761 and #30972531) from National Natural Science Foundation of China and partially funded by a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions. For the remaining authors none were declared.