Antisera to Human Renin Normalize Renin-Dependent Hypertension in the Monkey: Therapeutic Implications

Abstract

Polyclonal antisera raised against pure human renin normalize renin-dependent blood pressure elevation in the monkey (M. fascicularis). In vitro, comparable inhibition of either human or monkey plasma renin by the antisera was demonstrated. In vivo, intravenous infusion of 2 ml of antisera did not change mean arterial pressure of salt-repleted monkeys, however, its administration to salt-depleted monkeys with elevated plasma renin activity lowered mean arterial pressure 10 Torr.

Key Words:

• Renin
• Angiotensin
• Renovascular Hypertension
• Teprotide
• Converting Enzyme Inhibition
• Baroreflex