The Blood Pressure and Metabolic Effects of 19-Nor-Deoxycorticosterone and 19-Nor-Progesterone in Sheep

Campbell D. Spence Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052

John P. Coghlan Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052

Derek A. Denton Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052

Celso E. Gomez-sanchez Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, 33620, USA

Eric H. Mills Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052

Mark A. Nelson Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052

Judith A. Whitworth Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052; Department of Nephrology, Royal Melbourne Hospital, 3050, Australia

Bruce A. Scoggins Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, 3052

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Abstract

The present study examines the blood pressure and metabolic effects of 5 day infusions of 19-nor-deoxycorticosterone (19-nor-DOC) and 19- nor-progesterone (19-nor-PROG) in the intact conscious sheep. Both these steroids raise blood pressure in the rat.

19-nor-DOC (5 mg/d) produced a significant increase in mean arterial pressure (MAP) of 17 mmHg on day 5 (p < 0.001), associated with ‘mineralocorticoid’ effects hypokalaemia, hypernatraemia and an initial urinary sodium retention. In contrast 19-nor-PROG (5 mg/d and 50 mg/d) had no effect on EW and displayed no ‘mineralocorticoid’ activity.

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The Blood Pressure and Metabolic Effects of 19-Nor-Deoxycorticosterone and 19-Nor-Progesterone in Sheep

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The Blood Pressure and Metabolic Effects of 19-Nor-Deoxycorticosterone and 19-Nor-Progesterone in Sheep

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