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Abstract
A study was made of the effect of several antidepressive drugs with different mechanisms of action on cardiovascular response induced by clonidine (CLO) or guanabenz (GUA) in anaesthetized normotensive rats. The acute pretreatment (1 mg.kg−1) with desipramine (DMI), maprotiline (MAP) and mianserine (MIA) reduced the hypotensive and bradycardic responses induced by CLO (10 μg. kg−1), while only MIA prevented these central actions when elicited by GUA (30 μg.kg−1). Only chronic treatment with DMI reduced the hypotensive effect of CLO, but none of long-term antidepressant administrations decreased the fall in blood pressure induced by GUA. The long-term administration of DMI, MAP and MIA abolished the bradycardia from both agonists, CLO and GUA.