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Abstract
The effect of α-human atrial natriuretic factor(α-hANP, 10−6M- 10−8M) on basal, and maximum angiotensin II (All, 4.8 × 10−6 M)-, ACTH (4.3 × 10−9M)-, and potassium (8mM)-stimulated levels of corticosterone, 18-hydroxycorticosterone (18-OHB) and aldosterone production were studied in adrenal glomerulosa cells from spontaneously hypertensive rats (SHR) at 14 weeks of age as compared to those in the age-matched Wistar-Kyoto rats (WKY) on a normal sodium diet. Plasma corticosterone, 18-OHB and aldosterone levels and the aldosterone response in vitro to the graded doses of All were similar in SHR and WKY. Basal, and maximum AII-, ACTH-, and potassium-stimulated levels of corticosterone, 18-OHB and aldosterone also were similar in the ceils from SHR and WKY. α-hANP similarly inhibited basal and stimulated levels of these corticosteroids in the cells from SHR and WKY.
These results indicate that the inhibitory effect of α-hANP on aldosteronogenesis is unaltered in SHR at 14 weeks of age on a normal sodium diet.