Effect of Prolonged Angiotensin Converting Enzyme Inhibition on Ambulatory Blood Pressure of Normotensive Volunteers

J. Bidiville Division of Nephrology and Hypertension, University Hospital, 1011, Lausanne, Switzerland

J. P. Bussien Division of Nephrology and Hypertension, University Hospital, 1011, Lausanne, Switzerland

M. Porchet Division of Nephrology and Hypertension, University Hospital, 1011, Lausanne, Switzerland

J. Nussberger Division of Nephrology and Hypertension, University Hospital, 1011, Lausanne, Switzerland

B. Waeber Division of Nephrology and Hypertension, University Hospital, 1011, Lausanne, Switzerland

H. R. Brunner Division of Nephrology and Hypertension, University Hospital, 1011, Lausanne, Switzerland

Abstract

The blood pressure effect of 8-day angiotensin converting enzyme (ACE) inhibition was studied in normotensive healthy volunteers maintained on an unrestricted salt intake. Six volunteers received cilazapril (5 mg/day), 5 perindopril (8 mg/day) and 5 CGS14824A (10 mg/day). The 3 investigational inhibitors were found to have no consistent effect on blood pressure monitored during day-time outside the clinic using a semi-automatic blood pressure recorder (Remler M2000).

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Effect of Prolonged Angiotensin Converting Enzyme Inhibition on Ambulatory Blood Pressure of Normotensive Volunteers

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Effect of Prolonged Angiotensin Converting Enzyme Inhibition on Ambulatory Blood Pressure of Normotensive Volunteers

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