Inhibition of Hydrolytic Activities of Human Dipeptidases Toward Leukotriene D₄ and Kyotorphin by Capiopril

Y. Ito Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Osaka, 577, Japan

M. Iwaki Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Osaka, 577, Japan

T. Ogiso Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Osaka, 577, Japan

S. Nakamura Department of Internal Medicine, Aichi Medical University, Nagakute Aichi, 480-11, Japan

K. Kato Department of Internal Medicine, Aichi Medical University, Nagakute Aichi, 480-11, Japan

S. Sawaki Department of Internal Medicine, Aichi Medical University, Nagakute Aichi, 480-11, Japan

Abstract

We investigated inhibition by captopril of the hydrolysis of leukotriene D₄ (LTD₄) and kyotorphin by human dipeptidases (DPases). The rate or LTD₄ hydrolysis by kidney DPases F and S, pancreas and liver DPases were 60.6, 23.8, 23.3 and 0.358 units/mg protein, respectively. The inhibition by captopril was competitive for DPase F and liver DPase, and non-competitive for DPase S and pancreas enzyme. Using kyotorphin as a substrate, captopril inhibited four DPases competitively. From these results it is suggested that some side effects of captopril may relate to inhibition of hydrolytic activities of DPases with physiologically active dipeptides in man.

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Inhibition of Hydrolytic Activities of Human Dipeptidases Toward Leukotriene D₄ and Kyotorphin by Capiopril

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Inhibition of Hydrolytic Activities of Human Dipeptidases Toward Leukotriene D4 and Kyotorphin by Capiopril

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Inhibition of Hydrolytic Activities of Human Dipeptidases Toward Leukotriene D₄ and Kyotorphin by Capiopril