Effect of Chronic Treatment with Angiotensin I Converting Enzyme Inhibitors on Circulating Atrial Natriuretic Polypeptide in Spontaneously Hypertensive Rats

Masakazu Kohno The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

Kenichi Yasunari The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

Toshifumi Matsuura The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

Yoshiharu Kanayama The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

Kazuo Takaori The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

Koh-Ichi Murakawa The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

Tadanao Takeda The First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahimachi, Abenoku, Osaka, 545, Japan

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Abstract

We have recently shown that circulating atrial natriuretic polypeptide (ANP) in adult spontaneously hypertensive rats (SHR) is higher than that in age-matched Wistar-Kyoto rats (WKY). The present experiment was designed to examine the possible effects of chronic treatment with angiotensin I converting enzyme inhibitors (ACEI) on plasma ANP levels in SHR. Captopril and enalapril lowered blood pressure and reduced relative ventricular weight in SHR but not to the level of WKY. Plasma ANP levels were decreased by captopril and enalapril compared with untreated SHR. These results suggest that the ANP release may be suppressed in ACEI-treated SHR compared with untreated SHR. We speculate that a reduction of cardiac overload by ACEI may in part explain the decline of circulating ANP.

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Effect of Chronic Treatment with Angiotensin I Converting Enzyme Inhibitors on Circulating Atrial Natriuretic Polypeptide in Spontaneously Hypertensive Rats

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Effect of Chronic Treatment with Angiotensin I Converting Enzyme Inhibitors on Circulating Atrial Natriuretic Polypeptide in Spontaneously Hypertensive Rats

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