Re-Evaluation of the Plasma Renin-Angiotensin System in Anephric Patients

Abstract

In view of recent observations that a number of extrarenal tissues have the potential to produce angiotensin II and release it in a regulated fashion we made measurements of immunoreactive angiotensin I (irAng I) and angiotensin II (irAng II), along with active and inactive renin, and angiotensinogen in plasma of seven anephric patients and of 16 normal healthy volunteers to gain insight into possible sources of plasma Ang II. High performance liquid chromatography clearly demonstrated that the predominant component of irAng II in anephric plasma is the biologically active octapeptide Ang II. Plasma renin activity (PRA), and active

Key Words:

• Renin
• Angiotensinogen
• Angiotensin I
• Angiotensin II
• Anephrics