In SHR Rats, Dietary Potassium Determines NaCl Sensitivity in NaCl-Induced Rises of Blood Pressure

Abstract

The current study tested whether the spontaneously hypertensive rats (SHR) from Charles River Laboratories are resistant or not to NaCl-induced rises of blood pressure and deaths. These rats are fairly NaCl-resistant on a 2.1% high K diet, whereas they are quite susceptible to NaCl-induced hypertension and deaths on a 0.5% normal K diet. Thus, a high K diet strongly protects against a NaCl-induced rise of blood pressure as well as deaths in these SHR rats. Hence the level of dietary K determines the degree of NaCl sensitivity in these SHR rats.

Key Words:

• Potassium
• spontaneously hypertensive rats
• NaCl
• blood pressure