Decreased Cerebral Metabolism in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) with Stroke and its Possible Improvement by Solcoseryl®

Abstract

Local cerebral glucose utilization (LCGU) was decreased in SHRSP with stroke compared with normotensive Wistar rats. The decrement of LCGU was less in Solcoseryl®-treated SHRSP with stroke than that in saline-treated SHRSP with stroke and these brain areas where LCGU was less damaged, in Solcoseryl®-treated SHRSP were consistent with the important functioning sites of emotion, motor movement and memory. The result suggests that Solcoseryl® may be useful for metabolic improvement of the brain damage after stroke.

Key Words:

• Cerebral glucose utilization
• SHRSP
• stroke
• Solcoseryl®