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Clinical and Experimental Hypertension. Part A: Theory and Practice Volume 13, 1991 - Issue 8
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Original Article

Hormonal Correlates of Weight Loss Associated with Blood Pressure Reduction

P. Eggena Renin Biochemistry Laboratory, Veterans Affairs Medical Ctr, Sepulveda, California and the Department of Medicine, University of California, Los Angeles, California
,
J. R. Sowers Department of Medicine, Wayne State University, Detroit, Michigan
,
M. H. Maxwell Renin Biochemistry Laboratory, Veterans Affairs Medical Ctr, Sepulveda, California and the Department of Medicine, University of California, Los Angeles, California
,
J. D. Barrett Renin Biochemistry Laboratory, Veterans Affairs Medical Ctr, Sepulveda, California and the Department of Medicine, University of California, Los Angeles, California
&
M. S. Golub Renin Biochemistry Laboratory, Veterans Affairs Medical Ctr, Sepulveda, California and the Department of Medicine, University of California, Los Angeles, California
Pages 1447-1456 | Received 03 Oct 1990, Accepted 30 Jul 1991, Published online: 03 Jul 2009
 
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Abstract

This study investigated changes in plasma norepinephrine and the renin-angiotensin-aldosterone system during weight loss. Subjects were maintained on a hypocaloric and low sodium diet for 12 weeks. During weight loss statistically significant decreases in blood pressure, aldosterone, plasma renin activity, and norepinephrine were evident. Plasma renin substrate was suppressed from week one to eight and returned to control levels by week twelve. The data indicate that a reduction in the activity of the renin-angiotensin-aldosterone system, modulated by circulating norepinephrine and plasma renin substrate, may significantly contribute to the fall in blood pressure associated with weight loss.

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