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Abstract
The current understanding of the complex role of ROS in the organism and pathological sequelae of oxidative stress points to the necessity of comprehensive studies of antioxidant reactivities and interactions with cellular constituents. Studies of antioxidants performed within the COST B-35 action has concerned the search for new natural antioxidants, synthesis of new antioxidant compounds and evaluation and elucidation of mechanisms of action of both natural and synthetic antioxidants. Representative studies presented in the review concern antioxidant properties of various kinds of tea, the search for new antioxidants of herbal origin, modification of tocopherols and their use in combination with selenium and properties of two promising groups of synthetic antioxidants: derivatives of stobadine and derivatives of 1,4-dihydropyridine.
Declaration of interest: Support by the COST Action B35 and the Croatian Ministry of Science, Education and Sports, Agency of the Ministry of Education of the Slovak Republic for the Structural Funds of EU, Project: ‘ Evaluation of natural substances and their selection for prevention and treatment of lifestyle diseases ’ ITMS 26240220040, Slovak National grants AV 4/0013/07, APVV-51-017905, VEGA 2/0001/08, VEGA2/7074/27, VEGA 2/0083/09 and APVV 51-017905, and Polish grant 83/N-Cost/2007/0 grants is gratefully acknowledged.