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Abstract
In the tide of science nouveau after the completion of genome projects of various species, there appeared a movement to understand an organism as a system rather than the sum of cells directed for certain functions. With the advent and spread of microarray techniques, systematic and comprehensive genome-wide approaches have become reasonably possible and more required on the investigation of DNA damage and the subsequent repair. The immunoprecipitation-based technique combined with high-density microarrays or next-generation sequencing is one of the promising methods to provide access to such novel research strategies. Oxygen is necessary for most of the life on earth for electron transport. However, reactive oxygen species are inevitably generated, giving rise to steady-state levels of DNA damage in the genome, that may cause mutations leading to cancer, ageing and degenerative diseases. Previously, we showed that there are many factors involved in the genomic distribution of oxidatively generated DNA damage including chromosome territory, and proposed this sort of research area as oxygenomics. Recently, RNA is also recognized as a target of this kind of modification.
Declaration of interests
The authors declare no conflict of interest. This study was supported by Princess Takamatsu Cancer Research Fund (10-24213); a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan, a Grant-in Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and a Grant from Takeda Science Foundation.
This paper was first published online on Early Online on 10 November 2011.