Recognition of Cervical Neoplasia by the Estimation of a Free-Radical Reaction Product (Octadeca-9,H-Dienoic Acid) In Exfoliated Cells

S. K. Tay Department of Obstetrics and Gynaecology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK

A. Singer Department of Obstetrics and Gynaecology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK

J. F. A. Griffin Department of Obstetrics and Gynaecology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK; Department of Chemical Pathology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK

D. G. Wickens Department of Obstetrics and Gynaecology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK; Department of Chemical Pathology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK

T. L. Dormandy Department of Obstetrics and Gynaecology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK; Department of Chemical Pathology, Whittington Hospital, Highgate Hill, London, N19 5NF, UK

Abstract

The molar ratio between a diene-conjugated linoleic-acid isomer (18:2(9, 11)) and the parent linoleic acid (18:2(9, 12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer. The measurement may provide a simple and perhaps improved alternative to cytological screening.

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Recognition of Cervical Neoplasia by the Estimation of a Free-Radical Reaction Product (Octadeca-9,H-Dienoic Acid) In Exfoliated Cells

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Recognition of Cervical Neoplasia by the Estimation of a Free-Radical Reaction Product (Octadeca-9,H-Dienoic Acid) In Exfoliated Cells

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