Charge Transfer-Oxy Radical Mechanism for Anticancer Agents: mAMSA Derivatives, Rhodamine 123, and Nickel Salicylaldoximate

Philip W. Crawford Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA

Paavo Lumme Department of Chemistry, University of Helsinki, Vuorik 20, SF-00100, Helsinki, Finland

Hannu Elo Department of Chemistry, University of Helsinki, Vuorik 20, SF-00100, Helsinki, Finland

Michael D. Ryan Department of Chemistry, Marquette University, Milwaukee, WI, 53233, USA

Peter Kovacic Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA

Abstract

The proposal is advanced that many anticancer agents may function via redox reactions resulting in generation of toxic oxy radicals which destroy neoplastic cells. Cyclic voltammetry was performed with some of the main types: iminium ions (protonated mAMSA derivatives), quinone derivatives (rhodamine 123) and metal complexes (nickel(II) salicylaldoximate). In addition, relevant literature data are provided. A rationale is offered that relates electrochemical data to physiological activity.

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Charge Transfer-Oxy Radical Mechanism for Anticancer Agents: mAMSA Derivatives, Rhodamine 123, and Nickel Salicylaldoximate

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Charge Transfer-Oxy Radical Mechanism for Anticancer Agents: mAMSA Derivatives, Rhodamine 123, and Nickel Salicylaldoximate

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