Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog

Francisco J. Romero Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

Alfredo Montoro Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

Guillermo T. Sáez Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

Antonio Alberola Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

Francisco Gil Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

José Vina Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

Luis Such Departamentos de Fisiología y Bioquímica, Fucultad de Medicina, Universitat de València, Av. Blusco Ibanez, 17, E-46010, Valencia, Spain

show all

Abstract

Glutathione (GSH) decreases in dog mycocardium upon acute coronary occlusion when compared with sham-operated dogs. Total glutathione content (GSHeq = GSH + ZGSSG) remains unchanged throughout the experiment (6 h after surgery) in both sham- and acute coronary occlusion-operated dogs. GSSG and GSH/GSSG ratio increases and decreases respectively in all animals but tends to reach the normal value after 6 h in sham-operated dogs. Both parameters (GSSG and GSH/GSSG ratio) remain altered in acute coronary occlusion-operated ones. This alteration of glutathione status in ischemic myocardium is discussed.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog

Information for

Open access

Opportunities

Help and information

Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature