Metabolism of Phenyl and Alkyl Spin Adducts of PBN in Rat Hepatocytes. Rate Dependence on Size and Type of Addend Group

Abstract

The decay of the EPR signal of phenyl and alkyl spin adducts of PBN has been monitored in rat hepatocytes. The rate of decay depends on the length of the hydrocarbon chain as follows: n-hexyl > n-dodecyl > n-octadecyl. The rate of signal decay is faster in the membrane phase than in the aqueous phase for the phenyl spin adduct.

Key Words:

• α-phenyl-N-tert-butyl-nitrone
• PBN
• EPR
• spin adduct
• spin labeling
• hepatocyte
• metabolism