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Free Radical Research Volume 23, 1995 - Issue 3
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Original Article

Free Radical Dna Adduct 8-Oh-Deoxyguanosine Affects Activity of Hp a II and Msp I Restriction Endonucleases

Patrick W. Turk Division of Hematology/Oncology, Department of Medicine and Robert Lurie Cancer Center, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL, 60611, USA
&
Sigmund A. Weitzman Division of Hematology/Oncology, Department of Medicine and Robert Lurie Cancer Center, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL, 60611, USA
Pages 255-258 | Received 16 Jan 1995, Published online: 07 Jul 2009
 
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Abstract

8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.

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