The Copper Complex of Captopril is not a Superoxide Dismutase Mimic. Artefacts in DMPO Spin Trapping

Malgorzata Bartosz Department of Physiology, Institute of Fundamental Sciences, Military Medical University, Plac. J. Hallera No. 1, 90–647, Łódź, Poland

Józef Kedziora Department of Physiology, Institute of Fundamental Sciences, Military Medical University, Plac. J. Hallera No. 1, 90–647, Łódź, Poland

Grzegorz Bartosz Department of Molecular Biophysics, University of Łódź, Banacka 12/16, 90–2237, Łódź, PolandCorrespondence[email protected]

Abstract

The effect of captopril and of its copper complex on several superoxide-dependent reactions used to detect and assay superoxide dismutase activity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. ln none of these systems were superoxide dismutase-like properties of captopril/Cu apparent. Captopril/Cu decreased the yield of DMPO-OH adducts generated by KO₂ but this effect may be due to the acceleration of the decay of the adduct by captopril/Cu.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Copper Complex of Captopril is not a Superoxide Dismutase Mimic. Artefacts in DMPO Spin Trapping

Information for

Open access

Opportunities

Help and information

The Copper Complex of Captopril is not a Superoxide Dismutase Mimic. Artefacts in DMPO Spin Trapping

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature