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Free Radical Research Volume 28, 1998 - Issue 2
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Original Article

Studies of the Cellular Distribution of Superoxide Disrnutases in Adult and Fetal Rat Tissues

Bruce Mackler Department of Pediatrics, Division of Congenital Defects, Birth Defects Research Laboratory, Box 356320, University of Washington, Seattle, WA 98195, USA
,
Richard E. Person Department of Pediatrics, Division of Congenital Defects, Birth Defects Research Laboratory, Box 356320, University of Washington, Seattle, WA 98195, USA
,
Tien-Dat Nguyen Department of Pediatrics, Division of Congenital Defects, Birth Defects Research Laboratory, Box 356320, University of Washington, Seattle, WA 98195, USA
&
Alan G. Fantel Department of Pediatrics, Division of Congenital Defects, Birth Defects Research Laboratory, Box 356320, University of Washington, Seattle, WA 98195, USA
Pages 125-129 | Received 31 Jul 1997, Published online: 07 Jul 2009
 
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Abstract

Activities of three types of superoxide dismutase in tissue fractions were significantly lower in fetal and adult brain and fetal limb preparations than in fetal and adult heart preparations. An exception was the cyto-plasmic fraction of adult brain that had levels of Cu, Zn-superoxide dismutase activity comparable to those in cytoplasmic fractions of heart. In addition, Mn superoxide dismutase activity appeared to be very low in all fetal mitochondrial matrix fractions and cytoplasmic fractions as well as in adult brain. Finally, the results of these studies emphasize the importance of two antioxidant defense systems in the tissues studied, one associated with the mitochondrial electron transport system and the other, the cytosolic Cu, Zn enzyme.

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