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Drug Delivery Volume 23, 2016 - Issue 4: Liposome- and lipid-based drug delivery
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Research Article

Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy

Qian LiuCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People’s Republic of China, ;Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials, Ji'nan, Shandong, People’s Republic of China, and ;Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong, Ji'nan, Shandong, People’s Republic of China
,
Jia LiCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People’s Republic of China, ;Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials, Ji'nan, Shandong, People’s Republic of China, and ;Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong, Ji'nan, Shandong, People’s Republic of China
,
Gaobin PuCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People’s Republic of China, ;Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials, Ji'nan, Shandong, People’s Republic of China, and ;Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong, Ji'nan, Shandong, People’s Republic of China
,
Fang ZhangCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People’s Republic of China, ;Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials, Ji'nan, Shandong, People’s Republic of China, and ;Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong, Ji'nan, Shandong, People’s Republic of China
,
Hongyan LiuCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People’s Republic of China, ;Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials, Ji'nan, Shandong, People’s Republic of China, and ;Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong, Ji'nan, Shandong, People’s Republic of China
&
Yongqing ZhangCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People’s Republic of China, ;Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials, Ji'nan, Shandong, People’s Republic of China, and ;Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong, Ji'nan, Shandong, People’s Republic of ChinaCorrespondence[email protected]
Pages 1364-1368 | Received 10 Mar 2015, Accepted 16 Mar 2015, Published online: 15 Apr 2015
 
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Abstract

Purpose: Combination anticancer therapy is promising to generate synergistic anticancer effects, to maximize the treatment effect and to overcome multi-drug resistance. Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. The aim of this study is to construct a hyaluronic acid (HA) decorated NLCs as nanocarriers for co-delivery baicalein (BCL) and doxorubicin (DOX).

Methods: BCL- and DOX-loaded NLCs (BCL/DOX-NLCs) were prepared. HA ligands were used for the decoration of BCL/DOX-NLCs to form HA decorated BCL/DOX-NLCs (HA-BCL/DOX-NLCs). The in vitro cytotoxicity studies of different formulations were evaluated on DOX drug-resistant MCF-7 breast cancer cell line (MCF-7/ADR cells). In vivo anti-tumor effects were observed on the murine bearing MCF-7/ADR cells model.

Results: HA-BCL/DOX-NLCs showed highest cytotoxicity and synergistic effect of two drugs in tumor cells in vitro. The in vivo study revealed the greatest anti-tumor activity than all the other formulations in the murine breast cancer model.

Conclusions: HA decorated NLCs could be used as a novel carrier to co-delivery BCL and DOX for breast cancer therapy. HA-BCL/DOX-NLCs could be a promising targeted and combinational therapy nanomedicine.

Declaration of interest

The authors have no declarations of interest to report.

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