The application of antitumor drug-targeting models on liver cancer

Abstract

Hepatocarcinoma animal models, such as the induced tumor model, transplanted tumor model, gene animal model, are significant experimental tools for the evaluation of targeting drug delivery system as well as the pre-clinical studies of liver cancer. The application of antitumor drug-targeting models not only furnishes similar biological characteristics to human liver cancer but also offers guarantee of pharmacokinetic indicators of the liver-targeting preparations. In this article, we have reviewed some kinds of antitumor drug-targeting models of hepatoma and speculated that the research on this field would be capable of attaining a deeper level and expecting a superior achievement in the future.

• Animal models
• antitumor drugs
• gene knock-out
• liver cancer
• targeting agents

Declaration of interest

This work was financially supported by China Postdoctoral Science Foundation Funded Project (2014M562429) and Fundamental Research Funds for the Central University (xjj2013054 and xj08142016). The authors have no conflict of interest. The authors alone are responsible for the content and writing of this article.