Colonic targeting of metronidazole using azo aromatic polymers: Development and characterization

Abstract

A system for colonic targeting of metronidazole was developed by coating the drug-containing capsules with azoaromatic and pH-sensitive polymers that are prone to selective degradation in the colon environment. The azoaromatic polymers were synthesized by a bulk polymerization technique using different ratios of water-soluble and water-insoluble monomers. These polymers were characterized for physical attributes, namely film-forming properties, effect of colon bacterial flora, and pH. These polymers were then used to coat the delivery system bearing metronidazole. The systems were subjected to in vitro release and in vivo performance studies. The studies revealed that azoaromatic polymers are cleaved by the colonic microbiota and can be used successfully for colonic targeting of metronidazole.

Key Words :

• Azoaromatic Polymers
• Colonic Targeting
• Metronidazole