Potential signaling pathway of hypoxia-inducible factor in lung cancer and its gene polymorphism with lung cancer risk

Abstract

Lung cancer is becoming the leading cause of cancer death worldwide with highest morbidity and mortality, and knowing the pathogenesis and signaling pathway is very important and advances in the diagnosis and treatment of the disease are urgently needed. Gene polymorphism was reported to be associated with the lung cancer risk. We reviewed the potential signaling pathway of hypoxia-inducible factor in lung cancer and conducted a meta-analysis to explore its gene polymorphism with lung cancer risk. In the meta-analysis, hypoxia-inducible factor-1α (HIF-1α) G1790A A allele, AA genotype and GG genotype were associated with lung cancer risk (A allele: OR = 2.31, 95% CI: 1.77–3.02, p < 0.00001; AA genotype: OR = 4.52, 95% CI: 2.31–8.83, p < 0.0001; GG genotype: OR = 0.45, 95% CI: 0.33–0.63, p < 0.00001). Furthermore, HIF-1α C1772 TT genotype and CC genotype were associated with lung cancer risk, but the T allele was not. In conclusion, HIF-1α G1790A A allele, AA genotype and GG genotype, HIF-1α C1772 TT genotype and CC genotype were associated with lung cancer risk. However, more studies should be performed to confirm it.

• Hypoxia-inducible factor-1α
• lung cancer
• meta-analysis
• signaling pathway

Declaration of interest

The authors report no conflicts of interest.