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Abstract
Does disulfiram have a deleterious effect on neuropsychological functions? Neuropsychological test performance of 15 chronic alcoholics before and after being placed on disulfiram was compared with a similar group of 9 milieu-treated alcoholics also tested twice. Results indicated that (1) both groups showed a high incidence of significant neuropsychological impairment prior to either disulfiram or milieu treatment; (2) on second testing, both groups showed improved neuropsychological test performance. Disulfiram-treated alcoholics generally did not show increased neuropsychological impairment after being maintained on low dosages of this drug for 2 weeks. Certain results, however, suggest that the effect of disulfiram on short-term memory should be investigated.