Application of Artificial Neural Networks (ANN) in the Development of Solid Dosage Forms

ABSTRACT

The application of ANN in pharmaceutical development has been assessed using theoretical as well as typical pharmaceutical technology examples. The aim was to quantitatively describe the achieved data fitting and predicting abilities of the models developed with a view to using ANN in the development of solid dosage forms. The comparison between the ANN and a traditional statistical (i.e., response surface methodology, RSM) modeling technique was carried out using the squared correlation coefficient R². Using a highly nonlinear arbitrary function the ANN models showed better fitting (R² = 0.931 vs. R² = 0.424) as well as predicting (R² = 0.810 vs. R² = 0.547) abilities. Experimental data from a tablet compression study were fitted using two types of ANN models (i.e., multilayer perceptrons and a hybrid network composed of a self-organising feature map joined to a multilayer perceptron). The achiedved data fitting was comparable for the three methods (MLP R² = 0.911, SOFM-MLPR² = 0.850, and RSM R² = 0.897). ANN methodology represents a promising modeling technique when applied to pharmaceutical technology data sets.

Key Words: :

• Artificial neural networks (ANN)
• Associating networks
• Comparison of modeling techniques
• Feature-extracting networks
• Nonlinear function
• Pharmaceutical technology
• Response surface methodology (RSM)
• Tablet compression study