Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR VaBOMet)

Yukio Ando First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Hisayasu Terazaki First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Noriko Matsunaga First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Masayuki Ando First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Yuki Ohtsu Department of Forensic Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Shigeyuki Tsunenari Department of Forensic Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Kazuhiko Kibayashi Department of Forensic Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Masaaki Nakamura Department of Neurology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Eiko Ando Department of Ophthalmology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Konen Obayashi Department of Neurology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

Makoto Uchino Department of Neurology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

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Abstract

Twenty-nine-year-old twin brothers having the amyloidogenic transthyretin (ATTR) VaBOMet gene developed the clinical symptoms of familial amyloidotic polyneuropathy (FAP) in 1995. The twins had the same educational background and lived in the same district. FAP manifestations were similar in both cases, although electromyographic examinations revealed sensorimotor polyneuropathy in No. 1 and sensory polyneuropathy in No. 2. DNA analysis revealed that they were monozygotic twins. In addition to environmental factors, genetic factors may play an important role in determining the onset of FAP.

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Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR VaBOMet)

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Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR VaBOMet)

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