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Amyloid
The Journal of Protein Folding Disorders
Volume 10, 2003 - Issue 2
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Original Article

Myocardial adrenergic denervation in patients with primary (AL) amyloidosis

John Lekakis Department of Clinical Therapeutics, Athens University School of Medicine, Athens, Greece
,
Meletios A. Dirnopoulos Department of Clinical Therapeutics, Athens University School of Medicine, Athens, Greece
,
Vassilios Prassopoulos Department of Nuclear Medicine, Alexandra Hospital, Athens, Greece
,
Myron Mavrikakis Department of Clinical Therapeutics, Athens University School of Medicine, Athens, Greece
,
Sofia Cerali Department of Nuclear Medicine, Alexandra Hospital, Athens, Greece
,
Nicos Sifakis Department of Nuclear Medicine, Alexandra Hospital, Athens, Greece
,
Theodoros Athanassoulis Department of Nuclear Medicine, Alexandra Hospital, Athens, Greece
&
Stamatios Stamatelopoulos Department of Clinical Therapeutics, Athens University School of Medicine, Athens, Greece
 show all
Pages 117-120 | Received 07 May 2002, Accepted 15 Feb 2003, Published online: 06 Jul 2009
 
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Abstract

Three patients, 2 women and 1 man, with primary (AL) amyloidosis without congestive heart failure are described; all 3 patients presented reduced 1–123 metaiodo-benzylguanidine(MIBG) myocardial uptake suggesting marked cardiac sympathetic denervation. This is the first time myocardial adrenergic denervation is described in patients with AL amyloidosis without evidence of congestive heart failure; the observed denervation could be implicated in the pathogenesis of cardiac conduction disturbances which are common in this disease.

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