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Amyloid
The Journal of Protein Folding Disorders
Volume 20, 2013 - Issue 4
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Letter

Doxycycline in ATTRY69H (p.ATTRY89H) amyloidosis with predominant leptomeningeal manifestation

, , , , &
Pages 279-280 | Received 08 Jul 2013, Accepted 19 Jul 2013, Published online: 18 Sep 2013
 

Acknowledgements

Magnetic resonance imaging (MRI, ) was performed at the Department of Neuroradiology, LMU University Hospital Munich, in 2012.

Figure 1. Representative MRI of the brain in a patient with leptomeningeal ATTRY69H (p.ATTRY89H) amyloidosis showing abnormally increased leptomeningeal enhancement. Axial, gadolinium-enhancend T1-weighted sequence (TE/TR 17/580 ms; slice thickness 6 mm); 1.5 Tesla MR scanner (Magnetom Avanto, Siemens AG, Germany). A similar distribution pattern was also described in an ATTRY69H patient by Blevins et al. [Citation5].

Figure 1. Representative MRI of the brain in a patient with leptomeningeal ATTRY69H (p.ATTRY89H) amyloidosis showing abnormally increased leptomeningeal enhancement. Axial, gadolinium-enhancend T1-weighted sequence (TE/TR 17/580 ms; slice thickness 6 mm); 1.5 Tesla MR scanner (Magnetom Avanto, Siemens AG, Germany). A similar distribution pattern was also described in an ATTRY69H patient by Blevins et al. [Citation5].

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